Solid pseudopapillär tumör

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doi:10.1148/radiol.10092089 - Pubmed

  • 8.

    IHC

    Features:[4]

    • Beta-catenin +ve ~100% (cytoplasmic & nuclear).
    • E-cadherin +ve ~100% (cytoplasmic), -ve (membrane); antibody dependent.
    • CD10 +ve ~ 80% (cytoplasmic + dot-like) key.
    • Synaptophysin +ve (weak cytoplasmic) ~70%.
    • Progesterone receptor +ve (nuclear) key.

    Others:

    • CD56 +ve.
    • Chromogranin -ve.

    Memory device PCB: PR (nuclear), CD10 (cytoplasmic), beta-catenin (cytoplasmic & nuclear).

    They may occasionally present with a gradually enlarging abdominal mass or vague abdominal pain.

    The tumors frequently contain varying amounts of necrosis, hemorrhage, and cystic change.

    solid pseudopapillär tumör

    Humphreys G. In Memoriam. doi:10.1245/aso.2002.9.1.35 - Pubmed

  • 3. The cytoplasm, lightly eosinophilic to cleared, can have vacuoles (arrows). MR Imaging Features of Small Solid Pseudopapillary Tumors: Retrospective Differentiation From Other Small Solid Pancreatic Tumors. AJR Am J Roentgenol.

    Typical SPTs larger than 3 cm, and well-defined with central cystic and peripheral solid components.

    By Virginia Kneeland Frantz, M.D., Professor of Surgery, College of Physicians and Surgeons, Columbia University. Sunkara S, Williams T, Myers D, Kryvenko O. Solid Pseudopapillary Tumours of the Pancreas: Spectrum of Imaging Findings with Histopathological Correlation. World J Hepatol. 10⅕ × 7¾ In. Pp. 149, with 92 Illustrations. Yu M, Lee J, Kim M et al.

    Radiographics. Atlas of Tumor Pathology, Section VII, Fascicles 27 and 28. Pontrelli A, Di Meo G, Prete F, De Simone B, Testini M. Management and Outcomes of Solid Pseudopapillary Neoplasm of the Pancreas: A Systematic Review. AJR Am J Roentgenol. Zhang M, Duan Z, Li Z et al. Case report: solid-pseudopapillary tumour of the pancreas associated with dorsal agenesis.

    doi:10.1002/bjs.18004720344

  • 5. Diagnosen bör misstänkas vid hypervaskulära solida cystiska pankreaslesioner hos unga kvinnor och i tveksamma fall kan FNA med endoskopiskt ultraljud bekräfta den preoperativa diagnosen.10,11 För differentialdiagnos med neuroendokrina tumörer, av vilka de flesta uppvisar somatostatinreceptorer, skulle OctreoScan® kunna användas eftersom solida pseudopapillära neoplasmer saknar denna typ av receptorer.

    Den definitiva diagnosen fastställs genom biopsi, och den rekommenderade behandlingen är kirurgisk resektion.

    Martin R, Klimstra D, Brennan M, Conlon K. Solid-Pseudopapillary Tumor of the Pancreas: A Surgical Enigma? They tend to present in young non-White females around the 2nd and 3rd decades of life (the "daughter" tumor) 10.

    Associations

    Most patients are asymptomatic at diagnosis.

    Elevated β-HCG has been reported 15.

    Location

    There is a greater predilection to occur at the pancreatic tail.

    Ultrasound

    Large well-defined mass with heterogeneous appearances, due to its solid and cystic composition.

    CT

    Small atypical tumors are well marginated and solid with poor pancreatic phase enhancement, slowly progressing.

    Abdominal datortomografi och MRT (fig.